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Male Circumcision: The Priceless Cut? PDF Print E-mail
Written by Dipesh Pabari   
Thursday, 25 September 2008

Several years ago, I conducted an ethnographic study on people's knowledge, attitudes and beliefs towards medical research using a trial on male circumcision as a case study in a town in western Kenya.

For 9 months, I held hundreds of interviews and group discussions with the young, the old; the poor and the not-so poor; men and women. I would like to believe I really got to know people well, basically by hanging out with them as fellow human beings (many of whom I have developed close friendships with) rather than what is known in development and research as "participants". Terms, distinctions and categories disappeared and were replaced by focused bar talk. Given that our main topic of conversation was sex and western models of research, you can imagine we always had plenty to jazz about.

Six years later, CNN and Time declared male circumcision as the biggest medical breakthrough of 2007. Over 40 studies among heterosexuals in Africa, India and the U.S. have found between a two-fold and eight-fold increased risk of HIV acquisition in uncircumcised compared to circumcised men and it is now widely accepted that the majority of men who are HIV positive have been infected through the penis. The media moguls made their stand shortly after the World Health Organisation and UNAIDS publicly announced, 

that male circumcision performed by well-trained medical professionals was safe and reduced the risk of acquiring HIV infection by approximately 60%. The efficacy of male circumcision in reducing female to male transmission of HIV has been proven beyond reasonable doubt. This is an important landmark in the history of HIV prevention. 

The anti-circumcision lobby has a lot of issues with just how scientifically sound the evidence is given that the reality of implementing mass male circumcision is always very different from clinical controlled settings. In a recent scientific paper, co-author Travis claims that

the African studies were conducted in atypically sanitary clinics with highly skilled operators and cannot be extrapolated to the general population. The studies have been criticized for their poor science including: the men were paid to be circumcised, received free condoms and extensive education, and the studies were halted after only 21 to 24 month periods...Promoting circumcision will drain millions, possibly billions, of dollars away from more effective prevention strategies, and cause tens of thousands of infections and other surgical complications, further straining an already overwhelmed healthcare system and undermining the current ABC (abstinence, be faithful, and use condoms) campaigns by creating a false sense of immunity and increasing risk-taking behaviors. African males are already lining up to be circumcised, believing that they will no longer need to wear condoms, and this is a serious concern.

However, some African countries are convinced that male circumcision might offer part of the solution desperately needed now. In Uganda, the Ministry of Health has declared that male circumcision services will be free of charge while Rwanda has announced plans to conduct mass male circumcision and Kenya has recently followed suit. Principal Investigator for the Trial in western Kenya, Professor Bailey, is confident that this is what we have been waiting for:

If male circumcision is taken up by just 50% of men in areas of sub-Saharan Africa where it is currently little practiced, millions of new HIV infections will be averted in men and women. We cannot treat our way out of this tragic epidemic. Until we have an effective HIV vaccine, which is likely to be decade's away, circumcision is a major weapon for preventing new infections in areas where most HIV transmissions are acquired through heterosexual activity. The challenge is now to make safe, affordable circumcision services widely available to the many Africans who now are seeking them. 

Inevitably, there are concerns about how young circumcised men might perceive themselves to be fully protected and the trials did not divorce themselves from the importance of counseling. It is also true that millions of dollars have been poured into the research and lots more will go in to promoting male circumcision but does not compare in any way to the amount spent on vaccine trials and the scientists behind vaccine trials are the first to admit they are no closer to finding a vaccine then when they started. However, with 4000 new daily infections in male populations in Africa alone, there is a desperate need for a practical solution that does not depend on entirely on the will of the individual nor can Africa wait any longer for a vaccine. Slowing down the rate of new infections has to be a priority in order to give cultural and behavioral based models a chance.

Dipesh Pabari
About the author:
Dipesh Pabari is a Kenyan writer and freelance education and communications consultant. He sits on the Editorial Board for Awaaz Magazine (a journal for South Asians in diaspora) and Wajibu (a journal of ethical and social concern). 
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written by lmunala , September 26, 2008

In addition to men that have been circumcised having the perception of being fully protected from acquiring HIV/AIDS, the healing time after the procedure should also be explained to them by the health practitioners. Men are more infectious in the months following surgery, so having intercourse before they are fully healed is extremely risky for women. Male circumcision also does not decrease the rate of male to female transmission
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written by Amina , September 26, 2008
I have been skeptical about the prevalence of AIDS and circumcision. So I decided to read up on it. So I read up on it, and this why male circumcision reduces the female to male HIV infection (Leso, thanks for pointing that out):

Male circumcision offers additional protection from HIV because it reduces the possibility of tear and injury to the penis during sex and removes cells that are vulnerable to HIV infection. A circumcised penis also dries more quickly after sex. This may reduce the life-span of any HIV present after sex. Male circumcision reduces the risk of ulcerative sexually transmitted infections, such as syphilis, and reduces the risk of penile cancer. It has also been shown to reduce the risk of cervical cancer in women.


Dipesh, thanks for sharing this with us. It is important as you state that this sale of circumcision should come hand in hand with education on condoms, and monogamous relationships.
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written by Amina , September 26, 2008
http://data.unaids.org/pub/Man...ica_en.pdfUNAIDS report on male circumcision and HIV prevention.
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written by mkosakabila , September 26, 2008
Size Matters: The Number of Prostitutes and the Global HIV/AIDS Pandemic
http://www.medicalnewstoday.com/articles/74521.php
New study finds the key to understanding the global spread of AIDS is the size of the infected prostitute community around the world. The new study finds that the number of infected prostitutes in a country is the key to explaining the degree to which AIDS has infected the general population. Prostitute communities are typically very highly infected with the virus themselves, and because of the large number of sex partners they have each year, can act as an engine driving infection rates to unusually high levels in the general population. The new study is entitled "Size Matters: The Number of Prostitutes and the Global HIV/AIDS Pandemic" and is freely available online at the PLoS ONE publication website at www.plosone.org/doi/pone.0000543.

And now circumcision, the new panacea:

Circumcision Greatly Reduces Risk for HIV Infection
http://aids-clinical-care.jwat...006/1222/1

Adult male circumcision halved the risk for HIV transmission in an interim analysis of two randomized, controlled studies.....healthy HIV-negative men were randomized to receive circumcision immediately or to wait 2 years. All men received HIV prevention counseling, and follow-up was extensive....Among nearly 2800 volunteers in the Kenyan trial, HIV incidence was 53% lower in those who received circumcision than in controls. Among nearly 5000 volunteers in the Ugandan trial, HIV incidence was 48% lower in those who received circumcision.

What’s the likely mechanism of action for this protective effect?
Dr. Shapiro:
The most likely mechanism lies in the Langerhans cells, which are receptor cells for HIV. These cells are found in large numbers on the inner surface of the foreskin but are less common elsewhere on the surface of the penis. An intact foreskin may also be more susceptible to small tears or abrasions during sex. The rest of the male penis is heavily keritinized and, therefore, provides a less likely route of entry for HIV.


Cicum(de)cision: Preventing HIV but at what price?
http://www.nytimes.com/2007/04...cneil.html
In Africa, it is relatively easy to talk men into getting circumcised, said Daniel Halperin, an AIDS researcher at the Harvard School of Public Health who has interviewed hundreds of African men about sex, AIDS and local customs.


http://www.islamonline.net/ser.../HSELayout
Despite studies like this, the medical body is still divided on the preventative benefits male circumcision might have. One thing that some anti-circumcision researchers point out is why the United States has the highest rate of HIV infection amongst industrialized countries while the great majority of the male population in the United States is circumcised.

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written by mkosakabila , September 26, 2008
Doubts on Circumcision and HIV Risk Disappear
http://www.medpagetoday.com/HI...DS/tb/5121
The publication of two large African studies in the Feb. 24 issue of The Lancet brings to three the major trials that have found male circumcision helps prevent HIV.
All three were halted early after data monitoring committees found a significant benefit for the circumcised men.
•Circumcision Halves Risk of Heterosexual HIV Transmission;
Male Circumcision Equal to Vaccine in Preventing HIV Infection

The mechanism of the protection appears to relate to exposure of HIV target cells, according to Robert Bailey, Ph.D., of the University of Chicago, and colleagues, who led the Kenyan trial.
They wrote,
the inner mucosal surface of the human foreskin, exposed upon erection, has nine times higher density of HIV target cells (Langerhans' cells, CD4 T cells, and macrophages) than does cervical tissue. In addition, by contrast with the foreskin's inner surface, HIV target cells on the outer surface and the glans are protected by a layer of squamous epithelial cells.


Here’s their peers' reactions:

Bruno Leclercq, MD - Feb 26, 2007
This conclusion is a clear example of confusion. The population is anything but random, and the conclusion, for this very reason cannot be universal. The Kenyan population's social customs and behavior are not similar, by far, to those of the rest of the world. Personal hygiene and promiscuity are quite distinct, two factors that influence greatly the propagation of viruses. The same conclusion had been reached years ago about the link between circumcision and uterus cancer. The prevalence was less in the Azkhenasy population supposedly because of their 100% rate of circumcision. No one was taking into consideration the fact that the US population is nearly 100% circumcised. It is difficult not to see in this insistance on ritual mutilation anything but a social obsession with the sex organs. It is particularly clear in Africa where both sexes are mutilated, but in the west there is the sick maintenance of the episiotomy, a procedure that has been proven to be full of negative side effects.


Charles Geshekter, Ph.D. - Feb 26, 2007
Let's be quite clear about several things: First, the two studies from Kenya and Uganda failed to say anything about the actual HIV-status of the female partners, or the number of sexual partners of the cohort participants, or even what other conditions are known to trigger a positive HIV test result. Second, the studies revealed nothing about the prevalence of bacterial STDs (chlamydia or gonorrhea) among the female partners. Finally, the reports fail to draw a clear distinction between the clinical symptoms that define an AIDS case in Africa (the Bangui Definition) and the actually small number of cohort participants (65 out of 2800 in the Kenyan arm) said to have registered an HIV positive test result after 2 years in the study. For all these reasons, great care should accompany any reading of these results.


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written by Truthseeker , September 26, 2008
http://shailja.com/news/newsle...t-off.html
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written by Truthseeker , September 26, 2008
http://www.doctorsopposingcirc...ement.html

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written by images , September 29, 2008

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written by images , September 29, 2008















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written by Ajiambo , September 29, 2008
We say: There is lies, absolute lies, and statistics.

All the figures above are thus rendered useless, unless methodology of the research is explained.

At times me thinks not all people should be sent to school, because some have no business being there. Life is 70% common sense.

Am amazed at the fact that some people did not know that the simple act of sex traumatises the penis increasing its vulnerability to STDs.

We need WHO to release a study for us to know that? Africans have been genetically lobotomized.

Leso,
Stop speculating on how people will view the cut. Very simplistic reasoning right there!


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written by mkosakabila , October 01, 2008

If we suspend our disbelief for a moment, the figures above, especially for domestic violence are disturbing. How many more did not live to give an interview? Plus some correlation with HIV prevalence??

Of interest to me is how the last question (re circumstances where domestic violence is justified) was framed:
When is it OKAY for your husband to beat you?
Begging:
Have you experienced an OKAY beating in the past 12 months?
Domestic violence is generally unacceptable to me and think that if one were to dig even a little deeper, the likelihood that women are beaten up under circumstances they deem "unjustified" might be higher than under circumstances they deem "justified." I dont know.
But Faith Oneya's story caricatures this quite well.

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written by images , October 02, 2008
I posted these here to illustrate that circumcision or the lack of it (and the studies cited had major flaws) is not as big a factor in HIV prevalence as is made out.

The figures for violence against women suggest to me a possible reason for high prevalence in some regions, i.e. regions where women accept this much violence as justified, are unlikely to be regions where women can resist the sexual advances of diseased partners or insist on protected sex. Too much of a stretch?

The second chart, showing high prevalence rates in Nithi/ Tharaka/ Meru North and then also in Mbeere, Kuria and Migori or even Taita Taveta (these are among the top 5 nationwide) suggest again that circumcision or the lack of it is a poor explanation for high prevalence rates.

One thing that stands out, and which we ought to find an explanation for, is why in some communities the disparity between the male rate and the female one is so large. Consider the Meru, Kamba and Kisii males. To put it crudely, who are their women sleeping with? I have not seen any statistics indicating conclusively that some ethnicities are marrying off their daughters more than others, so why these disparities? The Kisii figure is particularly shocking, are Kisii men carrying natural immunity to the virus?

Why are women overall, so much more susceptible to the virus than men, and does this indicate limitations, even dangers of the mass circumcision model being pushed here?

The table on immunisation, suggests to me that particular population groups start already at a disadvantage. But the very very poor record of North Eastern province, juxtaposed against its very low HIV prevalence rate (someone cheekily suggests that female circumcision (or mutilation) can also be shown to be an impediment to HIV infection, under much the same arrangement as this study here, i.e. not having much sex cus of trauma to the general area, and risk of infection is very low.

Is the massive increase in poverty in Nyanza in the 1990s significant? The statistics do suggest that Luo Nyanza is one of the worst places to be a Kenyan, one of the worst places to be female. Don't take my word for it, look at the statistics, Pulling Apart.

I am still persuaded that poverty, nutrition and a lack of primary healthcare are more important factors than the presence or absence of a prepuce.
P.S. Surprisingly, Nyanza has a lot more high potential land than Central Province and many fewer landless poor.
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written by mkosakabila , October 02, 2008

If you look hard enough you’re likely to find studies that illustrate how domestic violence, esp sexual violence in marriage, correlate well with women’s HIV status and your explanation fits.

And higher prevalence among women than men? Maybe just more women get tested than men….!?

And now, a few more wild ones of my very own from the above data set—just don’t suspend your disbelief :

1.Poverty, broadly construed, very good for preventing HIV, as long as poverty is severe and stable and doesn’t increase esp in the 1990s. Just like a vaccine. Just look at North Eastern.
2.Good access to clean drinking water is also very good-- lowers HIV prevalence rates. Again, like a vaccine. Just look at North Eastern.

But great observations on circumcision, that being in Kenya too.

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written by Amina , October 02, 2008
Women generally get tested more than men because of pre-natal care thus the higher prevalence of HIV/AIDS infection among women than men.
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written by images , October 02, 2008
This does not make sense to me. If we are testing a larger group of women, that should lead to lower percentages, the bias would result from a small sample, not a large one. Unless of course we are suggesting such high incidence, that the probability of being HIV is greater than that of being negative. This is especially so as most of those who go for non-routine tests go because they suspect that they are infected, i.e. this sample is predisposed to have a much higher infection rate than the overall population.

Why women more? More women working as prostitutes (see mkosakabila's link above). I want to be adventurous and claim inferior nutrition, healthcare and immunity for many women. In general though, there is a greater surface area for entry in women, and this is why I am suggesting mass circumcision of the kind currently proposed could be more deleterious than helpful as it introduces all these sexually active, wounded males into the general population.



Curtains for me now. Hope the experts can intervene.
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written by Amina , October 02, 2008
Of interest to me is how the last question (re circumstances where domestic violence is justified) was framed:
When is it OKAY for your husband to beat you?
Begging:
Have you experienced an OKAY beating in the past 12 months?
Domestic violence is generally unacceptable to me and think that if one were to dig even a little deeper, the likelihood that women are beaten up under circumstances they deem "unjustified" might be higher than under circumstances they deem "justified." I don't know.
But Faith Oneya's story caricatures this quite well.


Interesting. Like you,there is no justification for beating a woman. However, I was recently shocked, when I heard a group of people, men and women, discuss how it is necessary to sometimes hit a woman. Shock on me!

Back to AIDS, you are right, that domestic violence does leave women vulnerable to HIV infections. Many instances, I have seen that the woman does not even have a choice on whether the couple use a condom or not.
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written by mkosakabila , October 02, 2008
Amina: those men and women are misguided. It is never necessary.

Images: Yes, let's hear from the experts--likely more to an explanation than just a sampling error. Too simple?

Honestly, editors, I'm not nitpicking or anything, but all the
sentences on this page (save for the quotes) have been cut off!
And remember we cant make headings anymore.
We are slowly losing things we had and no one cares.

mkosakabila,
Sorry, the problem you talk about is caused by the width of the images above. Readers using the Firefox browser will not be suffering this problem.

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Circumcision Benefit in AIDS Is Divided
written by Nekessa , October 09, 2008
According to an article in the NYT there is not enough evidence showing that male circumcision reduces AIDS acquisition:
The researchers based their conclusions on a review of 15 studies involving 53,567 gay and bisexual men in eight countries, including the United States, where nearly half of the 1.1 million people infected with the AIDS virus are men who have sex with men.

Circumcised men were 14 percent less likely to be infected with the human immunodeficiency virus, or H.I.V., than those who were uncircumcised, but the finding was not statistically significant, the researchers said.

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